Addition of grignard reagents to aryl acid chlorides: an efficient synthesis of aryl ketones.
نویسندگان
چکیده
[chemical reaction: see text]. Direct addition of Grignard reagents to acid chlorides in the presence of bis[2-(N,N-dimethylamino)ethyl] ether proceeds selectively to provide aryl ketones in high yields. A possible tridentate interaction between Grignard reagents and bis[2-(N,N-dimethylamino)ethyl] ether moderates the reactivity of Grignard reagents, preventing the newly formed ketones from nucleophilic addition by Grignard reagents.
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ورودعنوان ژورنال:
- Organic letters
دوره 7 25 شماره
صفحات -
تاریخ انتشار 2005